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Think about alternant therapies that aren't moderate CYP3A inducers all through therapy with mitapivat. If unable to prevent coadministration, keep an eye on Hb and titrate past 50 mg BID, if necessary, but never exceed mitapivat dose of 100 mg BID. .pentobarbital will lessen the extent or effect of bortezomib by affecting hepatic/intestinal enzyme